Furthermore, some studies have found that in rhabdomyolysis-induced acute kidney injury mice deficient in absent in melanoma 2 (AIM2), dsDNA released from injured muscle cells is turned to activate STING and increase the expression of IFN-1 and NF-κB, exacerbating inflammation and fibrosis due to the inability of AIM2 deficiency to scavenge inflammatory macrophages in time (Baatarjav et al., 2022). The gene discussed is AIM2; the disease is acute kidney injury.