STING1 and amyotrophic lateral sclerosis: In addition, the amplification of the GGGGCC sequence in the open reading frame 72 of chromosome 9p (C9ORF72) is directly related to the pathogenesis of most familial ALS (DeJesus-Hernandez et al., 2011; Renton et al., 2011), and deletion of C9ORF72 can promote STING-mediated IFN-1 production (McCauley et al., 2020).