PTGS2 and breast cancer: The risk of developing breast cancer can be increased by radiotherapy for existing malignancies, post-irradiation use of low-dose aspirin for 6 months in mice could prevent the establishment of an immunosuppressive tumor microenvironment, which was characterized by enriched proinflammatory factors and abundant myeloid cells, and aspirin intervention signiflcantly decreased COX-2 and TGFβ intensity in tumors from irradiated hosts (Ma L. et al., 2021).