Moreover, based on network pharmacology analysis, the therapeutic effect of VOA on myocardial ischemia may be mediated by COX-2, peroxisome proliferation-activated receptor (PPAR-α), vascular endothelial growth factor (VEGF) and cyclic adenosine monophosphate (cAMP) signalling pathways. This evidence concerns the gene VEGFA and myocardial ischemia.