BDNF and Anxiety: Studies have shown that α-asarone isolated from the volatile oil of ATT can regulate the activity of hypothalamic Fcorticotrophin-releasing factor (CR), change the central norepinephrine system, prevent the decrease of BDNF (brain-derived neurotrophic factor), tropomyosin receptor kinase (TrkB) expression in the hippocampus (Lee et al., 2014), decreased BDNF and TrkB expression in the hippocampus is the cause for the development of anxiety.