Meanwhile, various plant-derived natural compounds have been demonstrated to alleviate IBD by affecting the Keap1-Nrf2-ARE pathway in animal model systems of IBD, such as luteoline (Li et al., 2016), curcumin (Lin et al., 2019) and Flos puerariae extract (Yang et al., 2022) Therefore, the Nrf2 activator is considered as a potential drug for the treatment of IBD. This evidence concerns the gene KEAP1 and inflammatory bowel disease.