SOAT1 and inflammatory bowel disease: Some STAT inhibitors have also been studied in treating IBD, although no clinical trials have been conducted in patients with IBD (Kasembeli et al., 2018) Various plant-derived natural compounds such as curcumin, ellagic acid and paeonol have been proved to alleviate IBD by affecting the JAK-STAT pathway in IBD animal models (Marin et al., 2013; Yang et al., 2013; Moon et al., 2021).