The increased levels of IGF-1 observed in our cohort of patients, at six months follow-up, confirm the amelioration of metabolic profile; according with this lower IGF-1 levels have previously been shown to correlate with endothelial dysfunction (Sesti et al., 2014), so the increased levels of IGF-1 observed in our study may also explain the improvement of vascular function. This evidence concerns the gene IGF1 and endothelial dysfunction.