It is known that inflammation and oxidative stress, characterized by increased 8,12-isoprostane F (2α) concentration, low endothelium-bound extracellular superoxide dismutase activity and increased endothelium-bound xanthine oxidase (XO) activity and cytokines production, play a central role in pathogenesis of both endothelial dysfunction and HF (Bulua et al., 2011; Odegaard et al., 2016; Alem, 2019; Cassano et al., 2022). The gene discussed is XDH; the disease is endothelial dysfunction.