Conversely, with respect to RBCs from HD, 3-NT content is significantly (p < 0.05) higher in RBCs from long standing patients both at T0 and F.U. Significant differences (p < 0.05) between early -and long-standing RA patients (both T0 and F.U.)were found only for survivin and 3-NT (Figure 3). This evidence concerns the gene BIRC5 and rheumatoid arthritis.