Here, researches on the regulatory role of SNHG4 in MI showed that overexpression of SNHG4 inhibited cell apoptosis and inflammation and enhanced cell viability in both hypoxia-treated H9c2 cells and MI rats (hypoxia + pcDNA-SNHG4 vs. hypoxia, MI + Ad-SNHG4 vs. MI). This evidence concerns the gene SNHG4 and myocardial infarction.