HLA-C and acute graft versus host disease: The state-of-the-art Hu-PBL-NSG-MHCnull mouse model enables superior PBMC engraftment by preventing human T-cell recognition of murine MHC and the concomitant acute GVHD, but there are also limitations as other aspects of the human immune system may yet prove relevant to understanding the totality of the SCDI-immune interaction(122).