Analysis of MACC1 expression in COAD patients sub-grouped by clinical parameters showed that the levels of MACC1 mRNA were higher in COAD than in normal colon tissue samples in all patient subgroups based on age, gender, body mass index (BMI), race, carcinoembryonic antigen (CEA) levels, T stage, N stage, M stage, pathologic stage, perineural invasion and lymphatic invasion (Figure 5). Here, CEACAM5 is linked to colon adenocarcinoma.