Although MACC1 was shown to be a critical regulator and biomarker for progression and metastasis in over 20 types of cancer, including colon cancer, HCC, bladder cancer, and esophageal cancers [23–26], the mechanisms by which MACC1 is involved in the development and progression of COAD remain unclear. The gene discussed is MACC1; the disease is hepatocellular carcinoma.