AKT1 and pachyonychia congenita: But in the PC group, all the targeted genes were predominantly enriched in oncogenic pathways such as ERBB, mTOR, MAPK, TGF-beta, Hippo, and PI3K-AKT signaling pathways (p  <  0.001), while immune response pathways were secondary such as natural killer cell mediated cytotoxicity, antigen processing and presentation, and T cell receptor signaling pathway (p  <  0.001).