Glycogen synthase kinase 3β (Lauretti et al., 2020) (GSK3β), presenilin-1 (Lok et al., 2013) (PS1), and cyclin-dependent kinase 5 (Zhou et al., 2020) also affect vesicle trafficking in Alzheimer’s disease (Stokin and Goldstein, 2006). This evidence concerns the gene PSEN1 and early-onset autosomal dominant Alzheimer disease.