Therefore, herein we report in what circumstances acute emotional (depressive symptoms), cognitive (psychedelic experience), and physiological parameters (salivary cortisol) collected during ayahuasca and placebo dosing session in that RCT (8) moderated certain key MDD molecular biomarkers (serum BDNF, serum cortisol, serum interleukin 6, plasma CRP, and CAR) two days after intervention in patients with treatment-resistant depression versus a group of healthy volunteers. Here, CRP is linked to major depressive disorder.