Further, an increased expression of Urokinase Plasminogen-activator Receptor (uPAR) was observed in activated microglia in the brain of a patient with another neurodegenerative disease (Alzheimer’s disease), and uPAR expression was found to be mediated by oxidative stress-related mechanisms (Walker et al., 2002). This evidence concerns the gene PLAUR and early-onset autosomal dominant Alzheimer disease.