Wang et al. (2018c) showed that high MEG3 expression may suppress tumor cell proliferation and boost apoptosis by targeting PTEN. Another study pointed out that MEG3 was decreased in OC tissues and was negatively related to AGAP2 antisense RNA 1 (AGAP2-AS1). AGAP2-AS1 could downregulate the expression of MEG3 and promote OC cell proliferation (Chen et al., 2019). In addition, a recent study proposed that the serum level of MEG3 is a marker of high-grade OC tumor progression (Buttarelli et al., 2020). This evidence concerns the gene PTEN and neoplasm.