Not long after, a study reported that MEG3 regulates the PI3K/AKT/Bcl-2/Bax/Cyclin D1/p53 as well as PI3K/AKT/MMP-2/MMP-9 signaling pathways in PC to suppress tumor growth (Gu et al., 2017). This evidence concerns the gene AKT1 and pachyonychia congenita.