MEG3 and colorectal carcinoma: Another study pointed out that the MEG3/miR-103a-3p/pyruvate dehydrogenase E1 subunit beta (PDHB) pathway regulates cell proliferation, invasion, and ER stress, thus confirming the antitumor effects of abnormal expression of MEG3 and miR-103a-3p gene knockout in CRC progression (Wang et al., 2021a).