Yu et al. (2020b) analyzed that MEG3 regulates the expression of ALG9 by sponging miR-155, providing a new idea for the early diagnosis and chemotherapy resistance of AML. Similar results indicated that increased MEG3 expression modulated the expression of miR-147 to inhibit tumor cell proliferation and enhance apoptosis by modulating the JAK/STAT pathway (Li et al., 2018a). This evidence concerns the gene MEG3 and acute myeloid leukemia.