Wu et al. (2021) showed that m6A-induced MEG3 may inhibit the proliferation, migration and invasion via the MEG3/miR-544b/BTG2 axis in HCC. Yu et al. (2020c) reported that the demethylation reagent 5-AZa-CdR might upregulate the level of p53 to suppress the proliferation of MM cells by upregulating MEG3 expression. Studies have shown that overexpression of DNMT1 can lead to MEG3 gene promoter methylation and inactivation, which will promote RB cell proliferation (Gao et al., 2020). This evidence concerns the gene TP53 and hepatocellular carcinoma.