TNFRSF8 and lymphoma: Totally, 53 clinical trials of aptamer can be searched in NIH (clinicaltrials.gov) until October 2022; eight of them are related to different types of cancer, including CD30-positive lymphomas and solid malignancy imaging, preventing lung cancer in former smokers, acute myeloid leukemia treatment, targeting breast cancer, proteomic biomarker discovery in hepatocellular carcinoma, PET scan imaging in colorectal cancer, and molecular biosensors for the detection of bladder cancer(Table 1).