We selected the intersection of 135 up-regulated DEGs and 15 driver genes in the ME blue module as the feature genes of DCM with HF, with a total of 13 genes (OMD, PRELP, NPPA, LTBP2, C14orf132, FIBIN, SFRP4, FRZB, MFAP4, COL8A1, CFH, CTGF, ITGBL1) (Figure 5A). The gene discussed is MFAP4; the disease is familial dilated cardiomyopathy.