AKT1 and neoplasm: In addition, there were enrichments in Protein digestion and absorption (4th), ECM-receptor interaction (5th), NF-kappa B signaling pathway (7th), PI3K-Akt signaling pathway (8th), and Cell adhesion molecules (9th), demonstrating that the combination therapy had a widespread influence on the metabolism and metastasis of tumor cells (Figure 2B).