CD274 and Hodgkins lymphoma: Studies have shown that PD-L1 ligands are associated with 9p23-24 gene amplification (47) and that the 9p24 gene has a higher probability of mutation in Hodgkin’s lymphoma cells (48), whereas the gene is rarely altered in non-Hodgkin’s lymphoma cells (47), thus PD-1/PD-L1 blockade has shown better efficacy in the treatment of Hodgkin’s lymphoma.