High TIGIT+ cell density was also strongly associated with high TILs infiltrate (p<0.001), assessed using Salgado’s criteria (36) or with CD3 (p<0.001) and CD8 (p<0.001) markers, and with strong expression of PD-1 on stromal cells (p<0.001) and of PD-L1 on tumor and stromal cells (p<0.001 and p=0.003, respectively). Here, CD274 is linked to neoplasm.