In patients with active TB, a hyporesponsive T cell phenotype with decreased immune proliferation and decreased cytokine production induced by Mtb antigens and mitogens was associated with DNA hypermethylation of several immune genes and pathways, including the IL-2/STAT5, TNF/NF-κB, and IFN-γ signaling pathways (137). The gene discussed is TNF; the disease is tuberculosis.