IFNG and tuberculosis: observed that multiple genes of the IL-12/IFN-γ signaling pathway (IL12B, IL12RB2, TYK2, IFNGR1, JAK1, and JAK2) were hypermethylated in patients with active TB, with decreased IFN-γ–induced gene expression and decreased IL-12–inducible upregulation of IFN-γ (124).