AKT1 and hepatocellular carcinoma: Moreover, those important immune-related pathway, such as Intestinal immune network for IgA production, Fc gamma R-mediated phagocytosis, Antigen processing and presentation, Th1 and Th2 cell differentiation (Figure 6E), and cancer-related signaling pathways, such as MYC targets, G2 M checkpoint, activated E2F targets and PI3K-AKT-mTOR signaling (Figure 6F and Extended Data Figure S3), are closely related to the expression level of SMS in HCC when tested using GSEA, GSVA and ssGSEA.