First, the 15 kinds of m7G regulators were filtered through LASSO regression analysis, as shown in Figure 2A, when the best Log (ʎ) in the figure is equal to 5, the corresponding cross-validation error rate is the smallest, thus determining NSUN2, CYFIP1, EIF4E, NCBP1, and IFIT5 as signature genes of PAH. This evidence concerns the gene NSUN2 and pulmonary arterial hypertension.