Some organ-specific autoimmune disorders were observed in these patients including hematologic autoimmunity in patients with PNP, STIM1, ORAI1, WAS, ATM, and STAT5B mutations or early-onset inflammatory bowel disease in patients with WAS, DNMT3B, and ZBTB24 mutations (4). The gene discussed is ZBTB24; the disease is autoimmune disease.