The patients with ATM predominantly presented ataxia/telangiectasia (46.2%) and infections (32.1%), while allergy (52.6%) and infection (94.4%) were the dominant first manifestations in STAT3 (AD-LOF) and DNMT3B/ZBTB24 mutations, respectively. Here, ZBTB24 is linked to Ataxia-telangiectasia.