STAT3 and susceptibility to pneumonia measurement: In addition to the overall infection rate, the following types of infection were markedly different in the comparison: sinusitis [38.9% in DNMT3B/ZBTB24 mutations; p=0.021], pneumonia [77.8% in DNMT3B/ZBTB24 mutations; p=0.021], candidiasis [26.3% in STAT3 (AD-LOF) mutation; p=0.009], cutaneous infection [63.2% in STAT3 (AD-LOF) mutation; p<0.001], bronchiectasis [21.1% in STAT3 (AD-LOF) and 16.7% in DNMT3B/ZBTB24 mutations; p=0.028].