The frequency of autoimmune disorders in each diagnostic group was: 22.2% with DNMT3B/ZBTB24 [4 cases (ITP, RA, IBD)], 20% with WAS [2 cases (ITP)], 16.5% of patients with ATM [13 cases (ITP, AIHA, RA, IBD, psoriasis, SLE, AIH)], 15.8% with STAT3 AD (LOF) [3 cases (ITP, alopecia)], and 2 cases with PNP (AIH) and TTC7A mutations (autoimmune enteropathy). This evidence concerns the gene STAT3 and systemic lupus erythematosus.