Also, considering eczema is a risk factor for cutaneous infection (30), this type of infection was frequently detected in patients with mutated STAT3 (AD-LOF) and WAS. Furthermore, the higher frequency of sinusitis in patients with DNMT3B/ZBTB24 mutations might result from facial dysmorphisms associated with severe antibody production impairment. This evidence concerns the gene DNMT3B and Alzheimer disease.