In other frequently mutated genes, the type of mutations was the heterozygous deletion or point mutations in the STAT3, homozygous point mutations in the DNMT3B, and hemizygous point or deletion mutations in the WAS. Patients with WAS and ATM deficiencies showed slightly lower survival rate compared to other main monogenic syndromic CIDs (Figure S2). Here, STAT3 is linked to Wiskott-Aldrich syndrome.