Expression level of long-chain noncoding RNA-metastasis associated in lung adenocarcinoma transcript 1 (MALAT1) was significantly higher in CHB group than NASH group, suggesting that MALAT1 plays an important role in the HBV-infection-related inflammatory response of patients with chronic HBV infection and NAFLD. This evidence concerns the gene MALAT1 and metabolic dysfunction-associated steatotic liver disease.