CXCR6 and metabolic dysfunction-associated steatohepatitis: The presence of an exhausted, hepatic PD1+CD8+ T cell population, characterized by increased expression of C-X-C motif chemokine receptor 6 (CXCR6) and TNF-α in NASH mice, has been related with increased NASH progression to HCC, by possibly impairing immune surveillance (204).