Recently, using RNA-seq analysis, Geng and colleagues revealed that PD-L1 was upregulated on invasive lung fibroblasts and was associated with the invasive phenotype of lung fibroblasts, is regulated by p53 and focal adhesion kinase (FAK) pathways, and drives lung fibrosis in a humanized pulmonary fibrosis murine model (21). The gene discussed is TP53; the disease is pulmonary fibrosis.