Contradicting studies exist on s-CD95L; while soluble CD95L can trigger apoptosis and promote lung damage in acute lung injury (ALI) (51, 52), it fails to induce cell death but rather stimulates inflammation in chronic autoimmune disorders such as systemic lupus erythematosus (SLE) (34, 48) and metastasis occurrence in cancers (53–57). The gene discussed is FASLG; the disease is systemic lupus erythematosus.