The CD95/CD95L pair contributes to immune homeostasis and surveillance, and different mutations mainly localized within the CD95 death domain (DD), an intracellular region involved in the recruitment of the adaptor protein Fas-Associated protein with Death Domain (FADD), have been associated with breakdown of self-tolerance in autoimmune lymphoproliferative syndrome (ALPS) patients (27, 28) and LprCg mice (29, 30). Here, FAS is linked to autoimmune lymphoproliferative syndrome.