The amino acid metabolism-related proteins, including SHMT1, BHMT, AHCY, ALDH1L1, DDC, AOX1, AFMID, KYNU, and HAAO, were downregulated in ccRCC compared to adjacent normal tissue, while NNMT was upregulated in ccRCC compared to adjacent normal tissue (Figure 1A). The gene discussed is HAAO; the disease is nonpapillary renal cell carcinoma.