VEGF-A and PDGF-BB were chosen for their crucial involvement in (neo)-angiogenesis, TGF-β2 as an inducer of EMT that is an important contributor to tumor cell heterogeneity in HNSCC, and BDNF as a neurotrophin involved in perineural invasion of cancer cells. This evidence concerns the gene BDNF and head and neck squamous cell carcinoma.