EGFR and cancer: Based on the KEGG enrichment results, the potential mechanisms of marmesine in the treatment of OA are mainly involved in the proteoglycans in cancer, PI3K-Akt signaling pathway, microRNAs in cancer, MAPK signaling pathway, FoxO signaling pathway, Ras signaling pathway, HIF-1 signaling pathway, endocrine resistance, osteoclast differentiation, ErbB signaling pathway, and EGFR tyrosine kinase inhibitor signaling pathway (Figures 4(b) and 5).