Figueiredo et al. (20) reported that metformin affected hyperglycemia and hypertension (HTN) which are two main counter-regulators modulating DN in rats by inducing a significant increase in SOD, MDA, and urinary creatinine together with a significant decrease in serum insulin, glucose, triglycerides, total cholesterol, LDL, creatinine, urea, proteinuria, angiotensin II, and ABP. This evidence concerns the gene INS and liver dysplastic nodule.