The mechanism of SARS-CoV-2 infection inducing lupus nephritis may be related to the triggering of an intense immune response with the massive release of inflammatory cytokines such as interferon-gamma, tumor necrosis factor-alpha, interleukin-2 (IL-2), IL-6, IL-7, and IL-10, associated with the production of autoantibodies such as anti-cyclic citrullinated peptide antibody and antinuclear factor antibodies (25). The gene discussed is IFNG; the disease is lupus nephritis.