The diagnostic work-up for a patient with suspected VEXAS syndrome should include the characteristic cutaneous lesions (e.g., neutrophilic dermatitis, chondritis, vasculitis) and investigations of inflammatory markers (e.g., CRP, serum ferritin), a bone marrow biopsy, pulmonary imaging, pulmonary function tests, and the necessary investigations to rule out differential diagnoses. This evidence concerns the gene CRP and vasculitis.