INS and type 2 diabetes mellitus: According to the enrichment score, the top 10 significant pathways were the adipocytokine signaling pathway, the PPAR signaling pathway, the IL-17 signaling pathway, alcoholic liver disease, protein digestion and absorption, proximal tubule bicarbonate reclamation, insulin resistance, the TNF signaling pathway, type II diabetes mellitus, and cholesterol metabolism (Figure 4A).