AKT1 and familial pancreatic carcinoma: Upregulated genes were mostly associated with pancreatic cancer, TGF-β signaling pathway, AGE-RAGE signaling pathway in diabetic complications, growth hormone synthesis, secretion and action and phosphatidylinositol signaling system, whereas downregulated genes were mainly associated with proteoglycans in cancer, PI3K-Akt signaling pathway, fluid shear stress and atherosclerosis and regulation of actin cytoskeleton, as shown in Figures 6A,B.