SPIB is a member of the E-twenty-six (ETS) transcription factor family involved in regulating B cell development and differentiation (Xu et al., 2019) Moreover, previous studies have convinced SPIB as a novel prognostic biomarker in diffuse large B cell lymphoma that mediates apoptosis through the PI3K-AKT pathway (Takagi et al., 2016). This evidence concerns the gene AKT1 and diffuse large B-cell lymphoma.