Importantly many of these enriched proteins are known components of sub‐RPE deposits/drusen (e.g., clusterin, vimentin, collagen, S100‐A8 and fibronectin), and are associated with RPE dysfunction and stress, therefore constituting a risk for propagating the AMD phenotype to adjacent RPE or photoreceptor cells (Crabb, 2014; Crabb et al., 2002; Sakaguchi et al., 2002). This evidence concerns the gene FN1 and age-related macular degeneration.