To fully understand the role of EVs in the pathobiology of AMD, we focus herein on the molecular and functional characterisation of EVs secreted by the AMD‐patient derived induced pluripotent stem cell (iPSC) RPE cells with the common homozygous polymorphism in the complement factor H gene (CFH Y402H) and their role in disease signalling in the outer retina and AMD progression. This evidence concerns the gene CFH and age-related macular degeneration.