CTSD and age-related macular degeneration: Our previous work has shown that high‐risk AMD RPE cells are characterised by pronounced defects in autophagy, manifested by the expansion of the endolysosomal system, lysosomal membrane instability and reduced proteolytic activities, alongside with the deposition of key lysosomal components, such as Cathepsin D in drusen‐like deposits (Cerniauskas et al., 2020).