Additionally, the increased levels of CD63 tetraspanin in the AMD RPE cells (Cerniauskas et al., 2020) may influence enhanced intraluminal vesicles formation within MVBs (van Niel et al., 2011), that could be further stimulated by the increased levels of intracellular ceramides (Trajkovic et al., 2008) (findings of the current study). Here, CD63 is linked to age-related macular degeneration.