Also, increased RNA levels of SPP1 and CD63 in layer V microglia, SNCG, GLUL and CD63 in layer II/III astrocytes, CSRP1 in layer V neurons, and KIF5A in layer V and CD63 in layer II/III oligodendrocytes were found in human AD compared to CT cases (Fig. 7B). Here, SPP1 is linked to Alzheimer disease.