Layer- and cell-type-specific analysis showed the significant increase of the RNA levels of SLC1A3, KIF5A, C1QB and CRYAB in microglia, SLC1A3, KIF5A, CSRP1 and CRYAB in astrocytes, KIF5A, SNCG, STMN2, CD9, CD63, CRYAB and YWHAH in neurons, and CD9, SPP1, CD63 and CRYAB in oligodendrocytes in both layer II/III and layer V in human AD compared to CT cases (Fig. 7B). Here, CRYAB is linked to Alzheimer disease.