In this study, we confirm and extend our previous finding that tau368/t-tau is altered in AD and that it correlates with tau PET in patients with symptomatic AD [15] in brain regions associated with more advanced tau pathology (corresponding to neuropathological Braak stages III–IV and V–VI), while this association was less clear for p-tau181, p-tau217, and t-tau. The gene discussed is MAPT; the disease is Alzheimer disease.