PAPPA and Dravet syndrome: During the first-trimester the nuchal translucency (NT) screening was normal (1 mm); the pregnancy-associated plasma protein A (PAPP-A) and free beta-human chorionic gonadotropin (bHCG) were 28,600 U/L (0.7198 MoM) and 2310 lU/L (0.6233 MoM) respectively: the risk of having a baby with DS was calculated as 1:497 (base-risk) and 1:7536 (correct-risk).