Endogenous Cushing’s syndrome comprises two forms: adrenocorticotropic hormone (ACTH) dependent or ACTH independent; ACTH-producing pituitary adenoma and ectopic ACTH secretion by neoplasms cause ACTH-dependent Cushing’s syndrome, and adrenal hyperplasia, adenoma, and carcinoma are responsible for ACTH-independent Cushing’s syndrome [2]. Here, POMC is linked to Cushing syndrome due to macronodular adrenal hyperplasia.