The effector CD8+ T cells also express chemokine receptors with the capacity to dictate their migration to the sites of infection and/or inflammation where the secreted IFN-γ and TNF-α from the migrated effector CD8+ T cells can activate additional immune cells (e.g.,, monocytes, natural killer (NK) cells, T cells) and non-immune tissues like endothelial cells [16, 17]. The gene discussed is CD8A; the disease is infection.