The 11 pathways are listed in CTD as being related to obesity, and eight pathways are also related to PCOS, including, including PI3K-Akt signaling pathway, hepatitis C, prion diseases, staphylococcus aureus infection, chagas disease (American trypanosomiasis), cytokine–cytokine receptor interaction, glutathione metabolism, and arachidonic acid metabolism. This evidence concerns the gene AKT1 and Chagas disease.