GH1 and adrenal gland hyperfunction: For example, gradual decrease in the basal metabolic rate, dyslipidemia, stress-induced hypercortisolism, hypogonadism, decreased growth hormone secretion, concomitant insulin resistance, and abdominal fat deposition, changes of the functioning of beta cells and other environmental and physiological factors, may trigger a genetic expression of MetS which becomes more prominent with biological maturation [48, 49].