In this study, we speculate that Lewis y may regulate HERPUD1 to affect the PI3K/Akt/mTOR signaling pathway in the early stage of the tumor, promote autophagy of tumor cells, inhibit apoptosis, and provide tumor cells a selective advantage under the metabolic stress environment, to protect cancer cells from various forms of cellular stress and promote the survival of tumor cells. This evidence concerns the gene HERPUD1 and neoplasm.