AKT1 and neoplasm: In this study, we speculate that Lewis y may regulate HERPUD1 to affect the PI3K/Akt/mTOR signaling pathway in the early stage of the tumor, promote autophagy of tumor cells, inhibit apoptosis, and provide tumor cells a selective advantage under the metabolic stress environment, to protect cancer cells from various forms of cellular stress and promote the survival of tumor cells.