In summary, in the early stage of ovarian cancer, HERPUD1 is significantly overexpressed, and is regulated by Lewis y antigen, can promote the occurrence of autophagy and inhibit the apoptosis and EMT process by inhibiting the PI3K/AKT/mTOR and p38MAPK pathways, which provides favorable conditions for tumor cell survival under ERS in the early stage of ovarian cancer. This evidence concerns the gene HERPUD1 and ovarian cancer.