The statistical scatter plot of a single gene shows that the expression of HERPUD1 is significantly positively correlated with ARL2BP, AKTIP and DNAJB9 (Fig. 2d-f), which play an important role in regulating the integrity of microtubules, maintaining the cell cycle, maintaining telomere homeostasis, and protecting cells from apoptosis caused by ERS. The gene discussed is AKTIP; the disease is amelogenesis imperfecta type 1G.