Through String and GeneMANIA to perform PPI enrichment analysis (Fig. 3i, j), the results showed that proteins that interact with HERPUD1 are mainly enriched in the unfolded protein response (UPR) which is involved in regulating endoplasmic reticulum stress, ubiquitin-dependent degradation, assembly of multimeric protein complexes within the endoplasmic reticulum, protein transport, ERS-induced apoptosis, tumor metastasis, innate and adaptive immunity, and other processes. Here, HERPUD1 is linked to neoplasm.