In the current study, we subclassified 21 RA patients with OIIA TNK-LPDs into CD4+, CD8+, and CD4− CD8− phenotypes, and identified characteristic histological and immunohistological findings to EBV infection of atypical lymphocytes and scattered lymphocytes in the background, genetic findings, and prognostic factors, which were compared with those of OIIA and non-OIIA B-LPDs. The gene discussed is CD8A; the disease is Epstein-Barr virus infection.