CAVIN1 and Familial prostate cancer: Ligand-independent integrin activation is known to occur in response to changes in PM tension;84,85 thus, modulating the proportion of dolines (sensitive to low forces) versus ‘classic’ caveolae (sensing high forces) could be a means to fine-tune mechanically driven integrin signalling, explaining the association between invasive phenotypes and PTRF depletion displayed by prostate cancer cells86,87.