KLK3 and Familial prostate cancer: Zonal segmentation of the prostate plays a crucial role for prostate cancer detection as the PI-RADS score differs depending on the areas studied, based on diffusion-weighted imaging (DWI) for peripheral zone lesions and T2-weighted (T2W) imaging for transitional zone lesions, but also for multiple clinical application such as reproducible prostate volume and Prostate Specific Antigen (PSA) density evaluation [4], MRI-ultrasound fusion biopsy, radiotherapy, or focal planning.