We compared the clonogenic survival of non-tumorigenic breast epithelial (MCF10-2A) and breast cancer (MCF7) cell lines after single or double depletion of SETX and/or FANCD2, and that of parental FANCA-proficient, FANCA knock-out (FA-KO) or FANCA corrected (FA-corr) head and neck cancer (FaDu) cells after depletion of SETX. The gene discussed is SETX; the disease is breast cancer.