Here, we established a redox-related lncRNAs signature as a prognostic biomarker for HNSCC patients, which comprised ten lncRNAs related to redox genes, including AC133644.1, PTOV1-AS2, AL355488.1, LINC02446, DBH-AS1, AC010226.1, Z97653.1, LINC02084, MIR4435-2HG, and AC098487. This evidence concerns the gene DBH and head and neck squamous cell carcinoma.