KEGG pathway analyses revealed additional immune-related signaling pathways, such as “primary immunodeficiency”, “T cell receptor signaling pathway”, “Th17 cell differentiation”, “Th1 and Th2 cell differentiation”, “PD-L1 expression and PD-1 checkpoint pathway in cancer”, “Natural killer cell mediated cytotoxicity”, and so on (Fig. 6B). The gene discussed is PDCD1; the disease is cancer.