TIM3 is a negative immunological checkpoint that is critical in the inhibition of the immune system induced by tumors. Another research discovered that the transcription factor TIM3 was correlated with the immunosuppressive impact in HNSCC and that targeting TIM3 may boost anti-tumor immune reaction by attenuating Tregs activity in HNSCC64. The gene discussed is HAVCR2; the disease is head and neck squamous cell carcinoma.