Although plasma corticosterone dosage showed no differences among the four genotypes, plasma ACTH concentrations were elevated in Senp2cKO and reduced in Prkar1acKO, consistent with the corresponding associated disorders i.e. glucocorticoid deficiency and ACTH-independent glucocorticoid excess, respectively (Fig. 3e, f). The gene discussed is POMC; the disease is familial glucocorticoid deficiency.