Analysis of biopsied tumor specimens revealed the gene sets related to T cells, CD8 T cells, exhausted CD8 T cells, Treg cells, B cells, macrophages, CD45, mast cells, DCs, NK cells, CD56dim NK cells, cytotoxic cells, Th1 cells, and neutrophils between the BRAF wild-type (WT) and BRAF mutation (Mut) groups (Fig. 1A). The gene discussed is CD8A; the disease is neoplasm.